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4UVS

Crystal structure of human tankyrase 2 in complex with 5-amino-3- pentyl-1,2-dihydroisoquinolin-1-one

Summary for 4UVS
Entry DOI10.2210/pdb4uvs/pdb
Related4UVL 4UVN 4UVO 4UVP 4UVT 4UVU 4UVV 4UVW 4UVX 4UVY 4UVZ
DescriptorTANKYRASE-2, ZINC ION, SULFATE ION, ... (5 entities in total)
Functional Keywordstransferase, diphtheria toxin like fold, adp- ribosylation, transferase-transferase inhibitor complex
Biological sourceHOMO SAPIENS (HUMAN)
Total number of polymer chains2
Total formula weight55575.21
Authors
Narwal, M.,Haikarainen, T.,Lehtio, L. (deposition date: 2014-08-08, release date: 2015-07-29, Last modification date: 2024-01-10)
Primary citationPaine, H.A.,Nathubhai, A.,Woon, E.C.Y.,Sunderland, P.T.,Wood, P.J.,Mahon, M.F.,Lloyd, M.D.,Thompson, A.S.,Haikarainen, T.,Narwal, M.,Lehtio, L.,Threadgill, M.D.
Exploration of the Nicotinamide-Binding Site of the Tankyrases, Identifying 3-Arylisoquinolin-1-Ones as Potent and Selective Inhibitors in Vitro.
Bioorg.Med.Chem., 23:5891-, 2015
Cited by
PubMed: 26189030
DOI: 10.1016/J.BMC.2015.06.061
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2 Å)
Structure validation

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