4UVY
Crystal structure of human tankyrase 2 in complex with 3-(4- chlorophenyl)-5-methoxy-1,2- dihydroisoquinolin-1-one
Summary for 4UVY
Entry DOI | 10.2210/pdb4uvy/pdb |
Related | 4UVL 4UVN 4UVO 4UVP 4UVS 4UVT 4UVU 4UVV 4UVW 4UVX 4UVZ |
Descriptor | TANKYRASE-2, ZINC ION, SULFATE ION, ... (6 entities in total) |
Functional Keywords | transferase, protein-ligand complex, diphtheria toxin like fold, adp- ribosylation, transferase-transferase inhibitor complex |
Biological source | HOMO SAPIENS (HUMAN) |
Total number of polymer chains | 2 |
Total formula weight | 55870.24 |
Authors | Haikarainen, T.,Narwal, M.,Lehtio, L. (deposition date: 2014-08-08, release date: 2015-07-29, Last modification date: 2024-05-08) |
Primary citation | Paine, H.A.,Nathubhai, A.,Woon, E.C.Y.,Sunderland, P.T.,Wood, P.J.,Mahon, M.F.,Lloyd, M.D.,Thompson, A.S.,Haikarainen, T.,Narwal, M.,Lehtio, L.,Threadgill, M.D. Exploration of the Nicotinamide-Binding Site of the Tankyrases, Identifying 3-Arylisoquinolin-1-Ones as Potent and Selective Inhibitors in Vitro. Bioorg.Med.Chem., 23:5891-, 2015 Cited by PubMed: 26189030DOI: 10.1016/J.BMC.2015.06.061 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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