4UVU

Crystal structure of human tankyrase 2 in complex with 1-((4-(5- methyl-1-oxo-1,2-dihydroisoquinolin-3-yl)phenyl)methyl)pyrrolidin-1- ium

Summary for 4UVU

Entry DOI	10.2210/pdb4uvu/pdb
Related	4UVL 4UVN 4UVO 4UVP 4UVS 4UVT 4UVV 4UVW 4UVX 4UVY 4UVZ
Descriptor	TANKYRASE-2, 5-methyl-3-[4-(pyrrolidin-1-ylmethyl)phenyl]isoquinolin-1(2H)-one, ZINC ION, ... (6 entities in total)
Functional Keywords	transferase, diphtheria toxin like fold, adp- ribosylation, transferase-transferase inhibitor complex
Biological source	HOMO SAPIENS (HUMAN)
Total number of polymer chains	2
Total formula weight	56027.70
Authors	Haikarainen, T.,Narwal, M.,Lehtio, L. (deposition date: 2014-08-08, release date: 2015-07-29, Last modification date: 2019-02-06)
Primary citation	Paine, H.A.,Nathubhai, A.,Woon, E.C.Y.,Sunderland, P.T.,Wood, P.J.,Mahon, M.F.,Lloyd, M.D.,Thompson, A.S.,Haikarainen, T.,Narwal, M.,Lehtio, L.,Threadgill, M.D. Exploration of the Nicotinamide-Binding Site of the Tankyrases, Identifying 3-Arylisoquinolin-1-Ones as Potent and Selective Inhibitors in Vitro. Bioorg.Med.Chem., 23:5891-, 2015 Cited by PubMed: 26189030 DOI: 10.1016/J.BMC.2015.06.061 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation