4UVS

Crystal structure of human tankyrase 2 in complex with 5-amino-3- pentyl-1,2-dihydroisoquinolin-1-one

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003950	molecular_function	NAD+ ADP-ribosyltransferase activity
C	0003950	molecular_function	NAD+ ADP-ribosyltransferase activity

Functional Information from PDB Data

site_id	AC1
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 2163

Chain	Residue
A	CYS1081
A	HIS1084
A	CYS1089
A	CYS1092

---

site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN C 2162

Chain	Residue
C	CYS1081
C	HIS1084
C	CYS1089
C	CYS1092

---

site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 2163

Chain	Residue
C	HIS979
C	ARG980
C	LYS1067
C	ARG977

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 2164

Chain	Residue
A	ARG977
A	HIS979
A	ARG980
A	LYS1067
A	HOH3032

---

site_id	AC5
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 C 2164

Chain	Residue
C	ASN990
C	ARG991
C	PRO1160
C	GLU1161
C	HOH3039

---

site_id	AC6
Number of Residues	5
Details	BINDING SITE FOR RESIDUE SO4 A 2165

Chain	Residue
A	ASN990
A	ARG991
A	PRO1160
A	GLU1161
A	HOH3050

---

site_id	AC7
Number of Residues	9
Details	BINDING SITE FOR RESIDUE R4E A 2166

Chain	Residue
A	HIS1031
A	GLY1032
A	TYR1050
A	TYR1060
A	ALA1062
A	LYS1067
A	SER1068
A	TYR1071
A	GLU1138

---

site_id	AC8
Number of Residues	9
Details	BINDING SITE FOR RESIDUE R4E C 2165

Chain	Residue
C	HIS1031
C	GLY1032
C	PHE1035
C	TYR1050
C	TYR1060
C	LYS1067
C	SER1068
C	TYR1071
C	GLU1138

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	8
Details	BINDING: BINDING => ECO:0000250|UniProtKB:O95271

Chain	Residue	Details
A	CYS1081
A	HIS1084
A	CYS1089
A	CYS1092
C	CYS1081
C	HIS1084
C	CYS1089
C	CYS1092

---