4TQB

The co-complex structure of the translation initiation factor eIF4E with the inhibitor 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G

Summary for 4TQB

• Entry DOI: 10.2210/pdb4tqb/pdb
• Related: 4TPW 4TQC
• Descriptor: Eukaryotic translation initiation factor 4E, 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, (2E)-2-{2-[4-(4-bromophenyl)-1,3-thiazol-2-yl]hydrazinylidene}-3-(2-nitrophenyl)propanoic acid, ... (5 entities in total)
• Functional Keywords: eif4e, translation initiation inhibitor, allosteric, 4egi1, protein binding
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm, P-body: P06730
• Total number of polymer chains: 2
• Total formula weight: 46315.64

Authors

Papadopoulos, E.,Jenni, S.,Wagner, G. (deposition date: 2014-06-10, release date: 2014-08-13, Last modification date: 2023-12-27)

• Primary citation: Papadopoulos, E.,Jenni, S.,Kabha, E.,Takrouri, K.J.,Yi, T.,Salvi, N.,Luna, R.E.,Gavathiotis, E.,Mahalingam, P.,Arthanari, H.,Rodriguez-Mias, R.,Yefidoff-Freedman, R.,Aktas, B.H.,Chorev, M.,Halperin, J.A.,Wagner, G.; Structure of the eukaryotic translation initiation factor eIF4E in complex with 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G.; Proc.Natl.Acad.Sci.USA, 111:E3187-E3195, 2014; PubMed: 25049413; DOI: 10.1073/pnas.1410250111

Experimental method

X-RAY DIFFRACTION (1.59 Å)