4TQB
The co-complex structure of the translation initiation factor eIF4E with the inhibitor 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Eukaryotic translation initiation factor 4E | polymer | 191 | 22290.3 | 2 | UniProt (P06730) Pfam (PF01652) In PDB | Homo sapiens (Human) | eIF4E,eIF-4F 25 kDa subunit,mRNA cap-binding protein |
2 | A, B | 7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE | non-polymer | 539.2 | 2 | Chemie (MGT) | |||
3 | A | (2E)-2-{2-[4-(4-bromophenyl)-1,3-thiazol-2-yl]hydrazinylidene}-3-(2-nitrophenyl)propanoic acid | non-polymer | 461.3 | 1 | Chemie (34K) | |||
4 | A | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) | |||
5 | water | water | 18.0 | 594 | Chemie (HOH) |
Sequence modifications
A, B: 28 - 217 (UniProt: P06730)
PDB | External Database | Details |
---|---|---|
Met 27 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 44580.7 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 1735.0 | |
All* | Total formula weight | 46315.6 |