4TQB
The co-complex structure of the translation initiation factor eIF4E with the inhibitor 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003723 | molecular_function | RNA binding |
| A | 0003743 | molecular_function | translation initiation factor activity |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0006413 | biological_process | translational initiation |
| B | 0003723 | molecular_function | RNA binding |
| B | 0003743 | molecular_function | translation initiation factor activity |
| B | 0005737 | cellular_component | cytoplasm |
| B | 0006413 | biological_process | translational initiation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | binding site for residue MGT A 301 |
| Chain | Residue |
| A | TRP56 |
| A | HOH523 |
| A | HOH531 |
| A | HOH533 |
| A | HOH536 |
| A | HOH544 |
| A | HOH574 |
| A | HOH605 |
| A | HOH624 |
| B | THR55 |
| A | MET101 |
| A | TRP102 |
| A | GLU103 |
| A | ARG157 |
| A | LYS162 |
| A | GLY208 |
| A | HOH432 |
| A | HOH451 |
| site_id | AC2 |
| Number of Residues | 7 |
| Details | binding site for residue 34K A 302 |
| Chain | Residue |
| A | PHE47 |
| A | LYS49 |
| A | ASN59 |
| A | ARG61 |
| A | ILE63 |
| A | ILE79 |
| A | HOH406 |
| site_id | AC3 |
| Number of Residues | 8 |
| Details | binding site for residue MES A 303 |
| Chain | Residue |
| A | VAL69 |
| A | LEU135 |
| A | ARG186 |
| A | HOH417 |
| A | HOH514 |
| A | HOH517 |
| A | HOH627 |
| B | TRP73 |
| site_id | AC4 |
| Number of Residues | 15 |
| Details | binding site for residue MGT B 1000 |
| Chain | Residue |
| A | HOH451 |
| B | TRP56 |
| B | MET101 |
| B | TRP102 |
| B | GLU103 |
| B | ARG157 |
| B | LYS162 |
| B | HOH1117 |
| B | HOH1125 |
| B | HOH1239 |
| B | HOH1243 |
| B | HOH1246 |
| B | HOH1254 |
| B | HOH1268 |
| B | HOH1280 |
Functional Information from PROSITE/UniProt
| site_id | PS00813 |
| Number of Residues | 24 |
| Details | IF4E Eukaryotic initiation factor 4E signature. DYslFKdgIePmWEDeknkrGGRW |
| Chain | Residue | Details |
| A | ASP90-TRP113 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 28 |
| Details | Region: {"description":"EIF4EBP1/2/3 binding","evidences":[{"source":"PubMed","id":"16271312","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11879179","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"12975586","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16271312","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | Site: {"description":"(Microbial infection) Interaction with potato virus Y VPg","evidences":[{"source":"PubMed","id":"31712417","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | Modified residue: {"description":"Phosphoserine; by PKC and MKNK2","evidences":[{"source":"PubMed","id":"11154262","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"25923732","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7665584","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"7782323","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
