4S0V
Crystal structure of the human OX2 orexin receptor bound to the insomnia drug Suvorexant
Replaces: 4RNBSummary for 4S0V
Entry DOI | 10.2210/pdb4s0v/pdb |
Descriptor | Human Orexin receptor type 2 fusion protein to P. abysii Glycogen Synthase, [(7R)-4-(5-chloro-1,3-benzoxazol-2-yl)-7-methyl-1,4-diazepan-1-yl][5-methyl-2-(2H-1,2,3-triazol-2-yl)phenyl]methanone, OLEIC ACID, ... (4 entities in total) |
Functional Keywords | g protein-coupled receptor, orexin neurotransmitters, orexin receptor, orexin-a, orexin-b, suvorexant, n-linked glycosylation, signaling protein |
Biological source | Homo sapiens (human) More |
Cellular location | Cell membrane ; Multi- pass membrane protein : O43614 |
Total number of polymer chains | 1 |
Total formula weight | 64823.16 |
Authors | Yin, J.,Kolb, P.,Mobarec, J.C.,Rosenbaum, D.M. (deposition date: 2015-01-06, release date: 2015-01-14, Last modification date: 2023-09-20) |
Primary citation | Yin, J.,Mobarec, J.C.,Kolb, P.,Rosenbaum, D.M. Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant. Nature, 519:247-250, 2015 Cited by PubMed: 25533960DOI: 10.1038/nature14035 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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