5DEL
Crystal structure of Plasmodium falciparum dihydroorotate dehydrogenase bound with Inhibitor DSM59
Replaces: 4RYHSummary for 5DEL
Entry DOI | 10.2210/pdb5del/pdb |
Descriptor | Dihydroorotate dehydrogenase (quinone), mitochondrial, FLAVIN MONONUCLEOTIDE, OROTIC ACID, ... (7 entities in total) |
Functional Keywords | alpha/beta barrel, mitochondrial membrane, fmn, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Plasmodium falciparum |
Cellular location | Mitochondrion inner membrane ; Single-pass membrane protein : Q08210 |
Total number of polymer chains | 1 |
Total formula weight | 46737.09 |
Authors | Phillips, M.,Deng, X. (deposition date: 2015-08-25, release date: 2015-10-07, Last modification date: 2023-09-27) |
Primary citation | Deng, X.,Matthews, D.,Rathod, P.K.,Phillips, M.A. The X-ray structure of Plasmodium falciparum dihydroorotate dehydrogenase bound to a potent and selective N-phenylbenzamide inhibitor reveals novel binding-site interactions. Acta Crystallogr.,Sect.F, 71:553-559, 2015 Cited by PubMed: 25945708DOI: 10.1107/S2053230X15000989 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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