4RT7
Crystal Structure of FLT3 with a small molecule inhibitor
Summary for 4RT7
Entry DOI | 10.2210/pdb4rt7/pdb |
Descriptor | Receptor-type tyrosine-protein kinase FLT3, 1-(5-tert-butyl-1,2-oxazol-3-yl)-3-(4-{7-[2-(morpholin-4-yl)ethoxy]imidazo[2,1-b][1,3]benzothiazol-2-yl}phenyl)urea (3 entities in total) |
Functional Keywords | kinase, transferase, transferase inhibitor, complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: P36888 |
Total number of polymer chains | 1 |
Total formula weight | 48760.98 |
Authors | |
Primary citation | Smith, C.C.,Zhang, C.,Lin, K.C.,Lasater, E.A.,Zhang, Y.,Massi, E.,Damon, L.E.,Pendleton, M.,Bashir, A.,Sebra, R.,Perl, A.,Kasarskis, A.,Shellooe, R.,Tsang, G.,Carias, H.,Powell, B.,Burton, E.A.,Matusow, B.,Zhang, J.,Spevak, W.,Ibrahim, P.N.,Le, M.H.,Hsu, H.H.,Habets, G.,West, B.L.,Bollag, G.,Shah, N.P. Characterizing and Overriding the Structural Mechanism of the Quizartinib-Resistant FLT3 "Gatekeeper" F691L Mutation with PLX3397. Cancer Discov, 5:668-679, 2015 Cited by PubMed: 25847190DOI: 10.1158/2159-8290.CD-15-0060 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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