4RKJ

Crystal structure of thrombin mutant S195T (free form)

Summary for 4RKJ

• Entry DOI: 10.2210/pdb4rkj/pdb
• Related: 1SHH 4RKO
• Descriptor: Thrombin light chain, Thrombin heavy chain, POTASSIUM ION, ... (5 entities in total)
• Functional Keywords: trypsin-like proteases, catalysis, allosteric regulation, hydrolase
• Biological source: Homo sapiens (human); More
• Cellular location: Secreted, extracellular space: P00734 P00734
• Total number of polymer chains: 2
• Total formula weight: 33957.88

Authors

Pelc, A.L.,Chen, Z.,Gohara, D.W.,Vogt, A.D.,Pozzi, N.,Di Cera, E. (deposition date: 2014-10-13, release date: 2015-03-11, Last modification date: 2023-09-20)

• Primary citation: Pelc, L.A.,Chen, Z.,Gohara, D.W.,Vogt, A.D.,Pozzi, N.,Di Cera, E.; Why ser and not thr brokers catalysis in the trypsin fold.; Biochemistry, 54:1457-1464, 2015; PubMed: 25664608; DOI: 10.1021/acs.biochem.5b00014

Experimental method

X-RAY DIFFRACTION (1.7 Å)