4PZT

Crystal structure of p300 histone acetyltransferase domain in complex with an inhibitor, Acetonyl-Coenzyme A

Summary for 4PZT

Entry DOI	10.2210/pdb4pzt/pdb
Related	4PZR 4PZS
Descriptor	Histone acetyltransferase p300, [(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-4-HYDROXY-3-(PHOSPHONOOXY)TETRAHYDROFURAN-2-YL]METHYL (3R)-3-HYDROXY-2,2-DIMETHYL-4-OXO-4-{[3-OXO-3-({2-[(2-OXOPROPYL)THIO]ETHYL}AMINO)PROPYL]AMINO}BUTYL DIHYDROGEN DIPHOSPHATE, DIMETHYL SULFOXIDE, ... (4 entities in total)
Functional Keywords	transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: Q09472
Total number of polymer chains	1
Total formula weight	44759.68
Authors	Maksimoska, J.,Marmorstein, R. (deposition date: 2014-03-31, release date: 2014-06-11, Last modification date: 2023-09-20)
Primary citation	Maksimoska, J.,Segura-Pena, D.,Cole, P.A.,Marmorstein, R. Structure of the p300 Histone Acetyltransferase Bound to Acetyl-Coenzyme A and Its Analogues. Biochemistry, 53:3415-3422, 2014 Cited by PubMed: 24819397 DOI: 10.1021/bi500380f PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation