4PF9

Crystal structure of insulin degrading enzyme complexed with inhibitor

Summary for 4PF9

• Entry DOI: 10.2210/pdb4pf9/pdb
• Related: 4PES 4PF7
• Descriptor: Insulin-degrading enzyme, methyl [(2S)-2-[4-({5-[4-({(2S)-2-[(3S)-3-amino-2-oxopiperidin-1-yl]-2-cyclohexylacetyl}amino)phenyl]pentyl}oxy)phenyl]-3-(quinolin-3-yl)propyl]carbamate, ZINC ION, ... (4 entities in total)
• Functional Keywords: hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Cytoplasm: P14735
• Total number of polymer chains: 2
• Total formula weight: 230585.66

Authors

Wang, Y.,Guo, S. (deposition date: 2014-04-28, release date: 2015-06-17, Last modification date: 2023-09-27)

• Primary citation: Durham, T.B.,Toth, J.L.,Klimkowski, V.J.,Cao, J.X.,Siesky, A.M.,Alexander-Chacko, J.,Wu, G.Y.,Dixon, J.T.,McGee, J.E.,Wang, Y.,Guo, S.Y.,Cavitt, R.N.,Schindler, J.,Thibodeaux, S.J.,Calvert, N.A.,Coghlan, M.J.,Sindelar, D.K.,Christe, M.,Kiselyov, V.V.,Michael, M.D.,Sloop, K.W.; Dual Exosite-binding Inhibitors of Insulin-degrading Enzyme Challenge Its Role as the Primary Mediator of Insulin Clearance in Vivo.; J.Biol.Chem., 290:20044-20059, 2015; PubMed: 26085101; DOI: 10.1074/jbc.M115.638205

Experimental method

X-RAY DIFFRACTION (2.5 Å)