4P65

Crystal structure of an cyclohexylalanine substituted insulin analog.

Summary for 4P65
DescriptorInsulin, PHENOL, ZINC ION, ... (6 entities in total)
Functional Keywordsprotein hormone, non-standard mutagenesis, hormone
Biological sourceHomo sapiens (Human)
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Cellular locationSecreted: P01308 P01308
Total number of polymer chains12
Total formula weight35618.38
Authors
Pandyarajan, V.,Wan, Z.,Weiss, M.A. (deposition date: 2014-03-21, release date: 2014-10-22, Last modification date: 2014-12-31)
Primary citationCox, G.P.,Ismail-Beigi, F.,Lawrence, M.C.,Menting, J.G.,Pandyarajan, V.,Phillips, N.B.,Smith, B.J.,Wan, Z.L.,Weiss, M.A.,Whittaker, J.,Whittaker, L.,Wickramasinghe, N.
Aromatic Anchor at an Invariant Hormone-Receptor Interface: FUNCTION OF INSULIN RESIDUE B24 WITH APPLICATION TO PROTEIN DESIGN.
J.Biol.Chem., 289:34709-34727, 2014
PubMed: 25305014
DOI: 110.1074/jbc.M114.608562
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.5 Å)
Structure validation
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PDB entries from 2021-06-23