4OYS
CRYSTAL STRUCTURE OF VPS34 IN COMPLEX WITH SAR405.
Summary for 4OYS
Entry DOI | 10.2210/pdb4oys/pdb |
Descriptor | Phosphatidylinositol 3-kinase catalytic subunit type 3, SULFATE ION, (8S)-9-[(5-chloranylpyridin-3-yl)methyl]-2-[(3R)-3-methylmorpholin-4-yl]-8-(trifluoromethyl)-6,7,8,9a-tetrahydro-3H-pyrimido[1,2-a]pyrimidin-4-one, ... (4 entities in total) |
Functional Keywords | lipid kinase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 69427.51 |
Authors | Mathieu, M.,Marquette, J.p. (deposition date: 2014-02-13, release date: 2014-10-22, Last modification date: 2024-03-27) |
Primary citation | Ronan, B.,Flamand, O.,Vescovi, L.,Dureuil, C.,Durand, L.,Fassy, F.,Bachelot, M.F.,Lamberton, A.,Mathieu, M.,Bertrand, T.,Marquette, J.P.,El-Ahmad, Y.,Filoche-Romme, B.,Schio, L.,Garcia-Echeverria, C.,Goulaouic, H.,Pasquier, B. A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy. Nat.Chem.Biol., 10:1013-1019, 2014 Cited by PubMed: 25326666DOI: 10.1038/nchembio.1681 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.9 Å) |
Structure validation
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