4OC7

Retinoic acid receptor alpha in complex with (E)-3-(3'-allyl-6-hydroxy-[1,1'-biphenyl]-3-yl)acrylic acid and a fragment of the coactivator TIF2

Summary for 4OC7

• Entry DOI: 10.2210/pdb4oc7/pdb
• Descriptor: Retinoic acid receptor RXR-alpha, Nuclear receptor coactivator 2, (2E)-3-[6-hydroxy-3'-(prop-2-en-1-yl)biphenyl-3-yl]prop-2-enoic acid, ... (4 entities in total)
• Functional Keywords: ligand binding domain, transcription
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus : P19793 Q15596
• Total number of polymer chains: 2
• Total formula weight: 30132.72

Authors

Leysen, S.,Scheepstra, M.,Brunsveld, L.,Milroy, L.G.,Ottmann, C. (deposition date: 2014-01-08, release date: 2014-10-08, Last modification date: 2024-02-28)

• Primary citation: Scheepstra, M.,Nieto, L.,Hirsch, A.K.,Fuchs, S.,Leysen, S.,Lam, C.V.,in het Panhuis, L.,van Boeckel, C.A.,Wienk, H.,Boelens, R.,Ottmann, C.,Milroy, L.G.,Brunsveld, L.; A natural-product switch for a dynamic protein interface.; Angew.Chem.Int.Ed.Engl., 53:6443-6448, 2014; PubMed: 24821627; DOI: 10.1002/anie.201403773

Experimental method

X-RAY DIFFRACTION (2.5 Å)