4MDQ

Structure of a novel submicromolar MDM2 inhibitor

Summary for 4MDQ

Entry DOI	10.2210/pdb4mdq/pdb
Related	4MDN
Descriptor	E3 ubiquitin-protein ligase Mdm2, 3-[(1R)-2-(benzylamino)-1-{[(2S)-1-(hydroxyamino)-4-methyl-1-oxopentan-2-yl]amino}-2-oxoethyl]-6-chloro-N-hydroxy-1H-indole-2-carboxamide (3 entities in total)
Functional Keywords	mdm2, p53, cancer, small molecule, ligase-ligase inhibitor complex, ligase/ligase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Nucleus, nucleoplasm: Q00987
Total number of polymer chains	1
Total formula weight	11147.95
Authors	Bista, M.,Popowicz, G.,Holak, T.A. (deposition date: 2013-08-23, release date: 2013-11-13, Last modification date: 2024-02-28)
Primary citation	Bista, M.,Wolf, S.,Khoury, K.,Kowalska, K.,Huang, Y.,Wrona, E.,Arciniega, M.,Popowicz, G.M.,Holak, T.A.,Domling, A. Transient Protein States in Designing Inhibitors of the MDM2-p53 Interaction. Structure, 21:2143-2151, 2013 Cited by PubMed: 24207125 DOI: 10.1016/j.str.2013.09.006 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.119 Å)

Structure validation