4MDQ

Structure of a novel submicromolar MDM2 inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0043066	biological_process	negative regulation of apoptotic process
A	0051726	biological_process	regulation of cell cycle

Functional Information from PDB Data

site_id	AC1
Number of Residues	20
Details	BINDING SITE FOR RESIDUE 28W A 201

Chain	Residue
A	LEU54
A	HOH301
A	HOH301
A	HOH337
A	HOH348
A	HOH348
A	HOH349
A	HOH349
A	HOH350
A	HOH351
A	HOH352
A	PHE55
A	HOH359
A	PHE55
A	GLY58
A	GLY58
A	GLN59
A	MET62
A	HIS96
A	28W202

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site_id	AC2
Number of Residues	15
Details	BINDING SITE FOR RESIDUE 28W A 202

Chain	Residue
A	SER40
A	MET50
A	LYS51
A	LEU81
A	ASP84
A	ARG97
A	TYR100
A	28W201
A	HOH302
A	HOH308
A	HOH353
A	HOH354
A	HOH355
A	HOH356
A	HOH357

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