4MDQ
Structure of a novel submicromolar MDM2 inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | E3 ubiquitin-protein ligase Mdm2 | polymer | 86 | 10144.0 | 1 | UniProt (Q00987) Pfam (PF02201) | Homo sapiens (human) | Double minute 2 protein, Hdm2, Oncoprotein Mdm2, p53-binding protein Mdm2 |
| 2 | B, C (A) | 3-[(1R)-2-(benzylamino)-1-{[(2S)-1-(hydroxyamino)-4-methyl-1-oxopentan-2-yl]amino}-2-oxoethyl]-6-chloro-N-hydroxy-1H-indole-2-carboxamide | non-polymer | 502.0 | 2 | Chemie (28W) | |||
| 3 | D (A) | water | water | 18.0 | 86 | Chemie (HOH) |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 10144.0 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1003.9 | |
| All* | Total formula weight | 11147.9 |
