4MDN

Structure of a novel submicromolar MDM2 inhibitor

Summary for 4MDN

• Entry DOI: 10.2210/pdb4mdn/pdb
• Related: 4MDQ
• Descriptor: E3 ubiquitin-protein ligase Mdm2, 3-{(1S)-2-(tert-butylamino)-1-[{4-[(4-chlorobenzyl)oxy]benzyl}(formyl)amino]-2-oxoethyl}-6-chloro-1H-indole-2-carboxylic acid, SULFATE ION, ... (4 entities in total)
• Functional Keywords: mdm2, p53, cancer, small molecule, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus, nucleoplasm: Q00987
• Total number of polymer chains: 1
• Total formula weight: 11803.62

Authors

Bista, M.,Popowicz, G.,Holak, T.A. (deposition date: 2013-08-23, release date: 2013-11-13, Last modification date: 2024-02-28)

• Primary citation: Bista, M.,Wolf, S.,Khoury, K.,Kowalska, K.,Huang, Y.,Wrona, E.,Arciniega, M.,Popowicz, G.M.,Holak, T.A.,Domling, A.; Transient Protein States in Designing Inhibitors of the MDM2-p53 Interaction.; Structure, 21:2143-2151, 2013; PubMed: 24207125; DOI: 10.1016/j.str.2013.09.006

Experimental method

X-RAY DIFFRACTION (1.905 Å)