4MDN
Structure of a novel submicromolar MDM2 inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | E3 ubiquitin-protein ligase Mdm2 | polymer | 94 | 11029.0 | 1 | UniProt (Q00987) Pfam (PF02201) | Homo sapiens (human) | Double minute 2 protein, Hdm2, Oncoprotein Mdm2, p53-binding protein Mdm2 |
| 2 | B (A) | 3-{(1S)-2-(tert-butylamino)-1-[{4-[(4-chlorobenzyl)oxy]benzyl}(formyl)amino]-2-oxoethyl}-6-chloro-1H-indole-2-carboxylic acid | non-polymer | 582.5 | 1 | Chemie (Y30) | |||
| 3 | C, D (A) | SULFATE ION | non-polymer | 96.1 | 2 | Chemie (SO4) | |||
| 4 | E (A) | water | water | 18.0 | 71 | Chemie (HOH) |
Sequence modifications
A: 18 - 110 (UniProt: Q00987)
| PDB | External Database | Details |
|---|---|---|
| Met 17 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 11029.0 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 774.6 | |
| All* | Total formula weight | 11803.6 |
