4MDN

Structure of a novel submicromolar MDM2 inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0043066	biological_process	negative regulation of apoptotic process
A	0051726	biological_process	regulation of cell cycle

Functional Information from PDB Data

site_id	AC1
Number of Residues	13
Details	BINDING SITE FOR RESIDUE Y30 A 201

Chain	Residue
A	GLU23
A	TYR100
A	HOH328
A	HOH349
A	HOH356
A	LYS51
A	LEU54
A	PHE55
A	GLY58
A	ILE61
A	MET62
A	VAL93
A	HIS96

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 A 202

Chain	Residue
A	MET17
A	GLN18
A	HIS96
A	HOH342

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site_id	AC3
Number of Residues	2
Details	BINDING SITE FOR RESIDUE SO4 A 203

Chain	Residue
A	ARG97
A	HOH327

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