4LZ7

Crystal structures of GLuR2 ligand-binding-domain in complex with glutamate and positive allosteric modulators

Summary for 4LZ7

Entry DOI	10.2210/pdb4lz7/pdb
Related	4LZ5 4LZ8
Descriptor	Glutamate receptor 2, ZINC ION, GLUTAMIC ACID, ... (5 entities in total)
Functional Keywords	ampa receptor, allosteric modulator, transport protein
Biological source	Rattus norvegicus (brown rat) More
Cellular location	Cell membrane; Multi-pass membrane protein: P19491
Total number of polymer chains	3
Total formula weight	92410.65
Authors	Pandit, J. (deposition date: 2013-07-31, release date: 2013-12-04, Last modification date: 2023-09-20)
Primary citation	Patel, N.C.,Schwarz, J.,Hou, X.J.,Hoover, D.J.,Xie, L.,Fliri, A.J.,Gallaschun, R.J.,Lazzaro, J.T.,Bryce, D.K.,Hoffmann, W.E.,Hanks, A.N.,McGinnis, D.,Marr, E.S.,Gazard, J.L.,Hajos, M.,Scialis, R.J.,Hurst, R.S.,Shaffer, C.L.,Pandit, J.,O'Donnell, C.J. Discovery and Characterization of a Novel Dihydroisoxazole Class of alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) Receptor Potentiators. J.Med.Chem., 56:9180-9191, 2013 Cited by PubMed: 24215237 DOI: 10.1021/jm401274b PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation