4LZ7

Crystal structures of GLuR2 ligand-binding-domain in complex with glutamate and positive allosteric modulators

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C	Glutamate receptor 2	polymer	275	30343.8	3	UniProt (P19491) Pfam (PF10613) Pfam (PF00060) In PDB	Rattus norvegicus (brown rat)	GluR-2, AMPA-selective glutamate receptor 2, GluR-B, GluR-K2, Glutamate receptor ionotropic, AMPA 2, GluA2, AMPA receptor
2	A, B, C	ZINC ION	non-polymer		65.4	5	Chemie (ZN)
3	A, B, C	GLUTAMIC ACID	non-polymer		147.1	3	Chemie (GLU)
4	B, C	N-({(5S)-3-[3-fluoro-4-(pyrrolidin-1-yl)phenyl]-4,5-dihydro-1,2-oxazol-5-yl}methyl)acetamide	non-polymer		305.3	2	Chemie (1YW)
5		water	water		18.0	251	Chemie (HOH)

Sequence modifications

A, B, C: 383 - 506 (UniProt: P19491)

PDB	External Database	Details
Gly 378	-	expression tag
Ser 379	-	expression tag
Ala 380	-	expression tag
Met 381	-	expression tag
Gly 382	-	expression tag
Arg 389	Gly 410	engineered mutation
Gly 390	Leu 411	engineered mutation
Ala 391	Glu 412	engineered mutation

A, B, C: 632 - 775 (UniProt: P19491)

PDB	External Database	Details
Gly 507	-	linker
Thr 508	-	linker

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	91031.5
Non-Polymers*	Number of molecules	10
	Total formula weight	1379.1
All*	Total formula weight	92410.6

*Water molecules are not included.