4LZ7
Crystal structures of GLuR2 ligand-binding-domain in complex with glutamate and positive allosteric modulators
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| A | 0016020 | cellular_component | membrane |
| B | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| B | 0016020 | cellular_component | membrane |
| C | 0015276 | molecular_function | ligand-gated monoatomic ion channel activity |
| C | 0016020 | cellular_component | membrane |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN A 801 |
| Chain | Residue |
| A | GLU431 |
| A | HIS435 |
| B | GLU678 |
| B | HOH990 |
| site_id | AC2 |
| Number of Residues | 12 |
| Details | BINDING SITE FOR RESIDUE GLU A 802 |
| Chain | Residue |
| A | GLY653 |
| A | SER654 |
| A | THR655 |
| A | GLU705 |
| A | TYR732 |
| A | HOH1001 |
| A | HOH1007 |
| A | TYR450 |
| A | PRO478 |
| A | LEU479 |
| A | THR480 |
| A | ARG485 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ZN B 801 |
| Chain | Residue |
| B | HIS412 |
| B | GLU419 |
| B | HOH983 |
| C | HIS412 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE ZN B 802 |
| Chain | Residue |
| A | GLU678 |
| B | GLU431 |
| B | HIS435 |
| B | LEU753 |
| B | HOH998 |
| site_id | AC5 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE GLU B 803 |
| Chain | Residue |
| B | TYR450 |
| B | PRO478 |
| B | LEU479 |
| B | THR480 |
| B | ARG485 |
| B | LEU650 |
| B | GLY653 |
| B | SER654 |
| B | THR655 |
| B | GLU705 |
| B | TYR732 |
| B | HOH901 |
| B | HOH906 |
| B | HOH911 |
| site_id | AC6 |
| Number of Residues | 15 |
| Details | BINDING SITE FOR RESIDUE 1YW B 804 |
| Chain | Residue |
| B | LYS493 |
| B | PRO494 |
| B | PRO494 |
| B | PHE495 |
| B | MET496 |
| B | MET496 |
| B | SER497 |
| B | SER497 |
| B | SER729 |
| B | SER729 |
| B | LYS730 |
| B | LYS730 |
| B | ASN754 |
| B | HOH915 |
| B | HOH1007 |
| site_id | AC7 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ZN C 801 |
| Chain | Residue |
| A | HIS412 |
| C | ASP454 |
| site_id | AC8 |
| Number of Residues | 2 |
| Details | BINDING SITE FOR RESIDUE ZN C 802 |
| Chain | Residue |
| C | GLU431 |
| C | HIS435 |
| site_id | AC9 |
| Number of Residues | 14 |
| Details | BINDING SITE FOR RESIDUE GLU C 803 |
| Chain | Residue |
| C | TYR450 |
| C | PRO478 |
| C | LEU479 |
| C | THR480 |
| C | ARG485 |
| C | LEU650 |
| C | GLY653 |
| C | SER654 |
| C | THR655 |
| C | GLU705 |
| C | TYR732 |
| C | HOH902 |
| C | HOH904 |
| C | HOH910 |
| site_id | BC1 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE 1YW C 804 |
| Chain | Residue |
| A | LYS493 |
| A | PRO494 |
| A | PHE495 |
| A | MET496 |
| A | SER497 |
| A | SER729 |
| A | LYS730 |
| A | ASN754 |
| C | PRO494 |
| C | PHE495 |
| C | MET496 |
| C | SER497 |
| C | SER729 |
| C | LYS730 |
| C | GLY731 |
| C | ASN754 |
| C | HOH905 |
| C | HOH914 |
| C | HOH969 |
| C | HOH970 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 18 |
| Details | Binding site: {"evidences":[{"source":"PubMed","id":"11086992","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"16483599","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"1FTJ","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"2CMO","evidenceCode":"ECO:0007744"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI2 |
| Number of Residues | 9 |
| Details | Site: {"description":"Interaction with the cone snail toxin Con-ikot-ikot","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI3 |
| Number of Residues | 3 |
| Details | Site: {"description":"Crucial to convey clamshell closure to channel opening","evidences":[{"source":"PubMed","id":"25103405","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI4 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"Phosphoserine; by PKC","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
| site_id | SWS_FT_FI5 |
| Number of Residues | 3 |
| Details | Modified residue: {"description":"Phosphoserine; by PKG","evidences":[{"source":"PubMed","id":"8848293","evidenceCode":"ECO:0000269"}]} |
| Chain | Residue | Details |
