4LWU

The 1.14A Crystal Structure of Humanized Xenopus MDM2 with RO5499252

Summary for 4LWU

• Entry DOI: 10.2210/pdb4lwu/pdb
• Related: 4LWT 4LWV
• Descriptor: E3 ubiquitin-protein ligase Mdm2, (2'S,3R,4'S,5'R)-N-(4-carbamoylphenyl)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxamide, SULFATE ION, ... (4 entities in total)
• Functional Keywords: mdm2, spiroindolinone, e3 ubiquitin ligase, p53, nucleus, ligase-ligase inhibitor complex, ligase/ligase inhibitor
• Biological source: Xenopus laevis (clawed frog,common platanna,platanna)
• Cellular location: Nucleus, nucleoplasm (By similarity): P56273
• Total number of polymer chains: 1
• Total formula weight: 10510.96

Authors

Graves, B.J.,Lukacs, C.,Janson, C.A. (deposition date: 2013-07-28, release date: 2014-07-16, Last modification date: 2024-02-28)

• Primary citation: Zhang, Z.,Ding, Q.,Liu, J.J.,Zhang, J.,Jiang, N.,Chu, X.J.,Bartkovitz, D.,Luk, K.C.,Janson, C.,Tovar, C.,Filipovic, Z.M.,Higgins, B.,Glenn, K.,Packman, K.,Vassilev, L.T.,Graves, B.; Discovery of potent and selective spiroindolinone MDM2 inhibitor, RO8994, for cancer therapy.; Bioorg.Med.Chem., 22:4001-4009, 2014; PubMed: 24997575; DOI: 10.1016/j.bmc.2014.05.072

Experimental method

X-RAY DIFFRACTION (1.14 Å)