4L4M
Structural Analysis of a Phosphoribosylated Inhibitor in Complex with Human Nicotinamide Phosphoribosyltransferase
Summary for 4L4M
Entry DOI | 10.2210/pdb4l4m/pdb |
Related | 4L4L |
Descriptor | Nicotinamide phosphoribosyltransferase, N-{4-[(3,5-difluorophenyl)sulfonyl]benzyl}imidazo[1,2-a]pyridine-7-carboxamide, PHOSPHATE ION, ... (5 entities in total) |
Functional Keywords | transferase, inhibitor, active site, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Nucleus: P43490 |
Total number of polymer chains | 2 |
Total formula weight | 115243.62 |
Authors | |
Primary citation | Oh, A.,Ho, Y.C.,Zak, M.,Liu, Y.,Chen, X.,Yuen, P.W.,Zheng, X.,Liu, Y.,Dragovich, P.S.,Wang, W. Structural and biochemical analyses of the catalysis and potency impact of inhibitor phosphoribosylation by human nicotinamide phosphoribosyltransferase. Chembiochem, 15:1121-1130, 2014 Cited by PubMed: 24797455DOI: 10.1002/cbic.201402023 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.445 Å) |
Structure validation
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