4KJY
Complex of high-affinity SIRP alpha variant FD6 with CD47
Summary for 4KJY
Entry DOI | 10.2210/pdb4kjy/pdb |
Descriptor | Leukocyte surface antigen CD47, High-affinity SIRPa variant FD6, SULFATE ION, ... (5 entities in total) |
Functional Keywords | immunoglobulin fold, immune regulation, n-linked glycosylation, plasma membrane, immune system |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 59594.35 |
Authors | Ring, A.M.,Ozkan, E.,Ho, C.C.M.,Garcia, K.C. (deposition date: 2013-05-04, release date: 2013-06-12, Last modification date: 2020-07-29) |
Primary citation | Weiskopf, K.,Ring, A.M.,Ho, C.C.,Volkmer, J.P.,Levin, A.M.,Volkmer, A.K.,Ozkan, E.,Fernhoff, N.B.,van de Rijn, M.,Weissman, I.L.,Garcia, K.C. Engineered SIRP alpha variants as immunotherapeutic adjuvants to anticancer antibodies. Science, 341:88-91, 2013 Cited by PubMed: 23722425DOI: 10.1126/science.1238856 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.93 Å) |
Structure validation
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