4KEJ

Crystal structure of mouse Ryanodine Receptor 2 (1-217) disease mutant R169Q

Summary for 4KEJ

Entry DOI	10.2210/pdb4kej/pdb
Related	3IM5 3IM6 3IM7 3QR5 4KEI 4KEK
Descriptor	Ryanodine receptor 2 (2 entities in total)
Functional Keywords	ca2+ release, ion channel, er/sr membrane, metal transport
Biological source	Mus musculus (mouse)
Cellular location	Sarcoplasmic reticulum membrane; Multi-pass membrane protein (Probable): E9Q401
Total number of polymer chains	1
Total formula weight	24138.14
Authors	Kimlicka, L.,Van Petegem, F. (deposition date: 2013-04-25, release date: 2013-09-04, Last modification date: 2023-09-20)
Primary citation	Amador, F.J.,Kimlicka, L.,Stathopulos, P.B.,Gasmi-Seabrook, G.M.,Maclennan, D.H.,Van Petegem, F.,Ikura, M. Type 2 Ryanodine Receptor Domain A Contains a Unique and Dynamic alpha-Helix That Transitions to a beta-Strand in a Mutant Linked with a Heritable Cardiomyopathy. J.Mol.Biol., 425:4034-4046, 2013 Cited by PubMed: 23978697 DOI: 10.1016/j.jmb.2013.08.015 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.553 Å)

Structure validation