4K8V

Structure of cyclic GMP-AMP Synthase (cGAS)

Summary for 4K8V

Entry DOI	10.2210/pdb4k8v/pdb
Related	4K96 4K97 4K98 4K99 4K9A 4K9B
Descriptor	Cyclic GMP-AMP synthase, ZINC ION (3 entities in total)
Functional Keywords	nucleotidyltransferase, dna, transferase
Biological source	Mus musculus (mouse)
Cellular location	Cytoplasm, cytosol: Q8C6L5
Total number of polymer chains	4
Total formula weight	170310.12
Authors	Gao, P.,Wu, Y.,Patel, D.J. (deposition date: 2013-04-18, release date: 2013-05-15, Last modification date: 2024-02-28)
Primary citation	Gao, P.,Ascano, M.,Wu, Y.,Barchet, W.,Gaffney, B.L.,Zillinger, T.,Serganov, A.A.,Liu, Y.,Jones, R.A.,Hartmann, G.,Tuschl, T.,Patel, D.J. Cyclic [G(2',5')pA(3',5')p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase. Cell(Cambridge,Mass.), 153:1094-1107, 2013 Cited by PubMed: 23647843 DOI: 10.1016/j.cell.2013.04.046 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation