4K4H

Ternary crystal structures of a human DNA POLYMERASE LAMBDA IN COMPLEX WITH DNA AND (-)3TC-TP.

Summary for 4K4H

• Entry DOI: 10.2210/pdb4k4h/pdb
• Related: 4K4G 4K4I
• Descriptor: DNA polymerase lambda, DNA (5'-D(*CP*GP*GP*CP*GP*GP*TP*AP*CP*TP*G)-3'), DNA (5'-D(*CP*AP*GP*TP*AP*C)-3'), ... (8 entities in total)
• Functional Keywords: dna polymerase, dna repair, phosphoryl transfer reaction, transferase-dna complex, transferase/dna
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 16
• Total formula weight: 181613.08

Authors

Vyas, R.,Suo, Z. (deposition date: 2013-04-12, release date: 2014-07-16, Last modification date: 2024-03-13)

• Primary citation: Vyas, R.,Zahurancik, W.J.,Suo, Z.; Structural basis for the binding and incorporation of nucleotide analogs with L-stereochemistry by human DNA polymerase lambda.; Proc.Natl.Acad.Sci.USA, 111:E3033-E3042, 2014; PubMed: 25015085; DOI: 10.1073/pnas.1401286111

Experimental method

X-RAY DIFFRACTION (2.1 Å)