4K4H

Ternary crystal structures of a human DNA POLYMERASE LAMBDA IN COMPLEX WITH DNA AND (-)3TC-TP.

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, E, I, M (A, E, I, M)	DNA polymerase lambda	polymer	340	38254.6	4	UniProt (Q9UGP5) Pfam (PF14716) Pfam (PF10391) Pfam (PF14792) Pfam (PF14791)	Homo sapiens (human)	Pol Lambda, DNA polymerase beta-2, Pol beta2, DNA polymerase kappa
2	B, F, J, N (B, F, J, N)	DNA (5'-D(*CP*GP*GP*CP*GP*GP*TP*AP*CP*TP*G)-3')	polymer	11	3390.2	4		Homo sapiens
3	C, G, K, O (C, G, K, O)	DNA (5'-D(*CP*AP*GP*TP*AP*C)-3')	polymer	6	1793.2	4		Homo sapiens
4	D, H, L, P (D, H, L, P)	DNA (5'-D(P*GP*CP*CP*G)-3')	polymer	4	1191.8	4		Homo sapiens
5	GA, NA, Q, Z (I, M, A, E)	Lamivudine Triphosphate	non-polymer		469.2	4	Chemie (1RZ)
6	AA, BA, CA, DA, EA... (E, F, I, J, M...)	CALCIUM ION	non-polymer		40.1	23	Chemie (CA)
7	FA, LA, TA, UA, X (F, I, M, A)	ACETATE ION	non-polymer		59.0	5	Chemie (ACT)
8	AB, BB, CB, DB, EB... (E, F, G, H, I...)	water	water		18.0	491	Chemie (HOH)

Sequence modifications

A, E, I, M: 245 - 575 (UniProt: Q9UGP5)

PDB	External Database	Details
Met 244	-	expression tag
Leu 576	-	expression tag
Glu 577	-	expression tag
His 578	-	expression tag
His 579	-	expression tag
His 580	-	expression tag
His 581	-	expression tag
His 582	-	expression tag
His 583	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	16
	Total formula weight	178519.3
Non-Polymers*	Number of molecules	32
	Total formula weight	3093.8
All*	Total formula weight	181613.1

*Water molecules are not included.