4K45

Auto-inhibition and phosphorylation-induced activation of PLC-gamma isozymes

Summary for 4K45

• Entry DOI: 10.2210/pdb4k45/pdb
• Related: 3GQI 4K44
• Descriptor: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1, short peptide (3 entities in total)
• Functional Keywords: sh2 domain, plc-gamma1, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Rattus norvegicus (rat); More
• Cellular location: Cell projection, lamellipodium (By similarity): P10686 P10686
• Total number of polymer chains: 2
• Total formula weight: 14554.31

Authors

Sondek, J.,Hajicek, N. (deposition date: 2013-04-11, release date: 2013-06-26, Last modification date: 2014-01-22)

• Primary citation: Hajicek, N.,Charpentier, T.H.,Rush, J.R.,Harden, T.K.,Sondek, J.; Autoinhibition and Phosphorylation-Induced Activation of Phospholipase C-gamma Isozymes.; Biochemistry, 52:4810-4819, 2013; PubMed: 23777354; DOI: 10.1021/bi400433b

Experimental method

X-RAY DIFFRACTION (1.5 Å)