4K45
Auto-inhibition and phosphorylation-induced activation of PLC-gamma isozymes
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 27 |
| Details | BINDING SITE FOR CHAIN B OF 1-PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE PHOSPHODIESTERASE 4,5-BISPHOSPHATE PHOSPHODIESTERASE GAMMA-1 |
| Chain | Residue |
| A | ARG675 |
| A | PRO745 |
| A | LEU746 |
| A | ARG748 |
| A | ARG753 |
| A | TYR754 |
| A | PRO755 |
| B | HOH801 |
| B | HOH802 |
| B | HOH803 |
| B | HOH804 |
| A | GLN677 |
| B | HOH805 |
| B | HOH807 |
| B | HOH808 |
| B | HOH809 |
| B | HOH810 |
| B | HOH811 |
| B | HOH812 |
| B | HOH813 |
| A | ARG694 |
| A | ARG696 |
| A | HIS714 |
| A | CYS715 |
| A | ARG716 |
| A | LEU726 |
| A | ASN728 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine; by SYK => ECO:0000250|UniProtKB:P08487 |
| Chain | Residue | Details |
| B | TYR771 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P19174 |
| Chain | Residue | Details |
| B | TYR775 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphotyrosine; by ITK, SYK and TXK => ECO:0000250|UniProtKB:P19174 |
| Chain | Residue | Details |
| B | PTR783 |
