4K44

Auto-inhibition and phosphorylation-induced activation of PLC-gamma isozymes

Summary for 4K44

Entry DOI	10.2210/pdb4k44/pdb
Related	3GQI 4K45
Descriptor	1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (2 entities in total)
Functional Keywords	sh2 domain, hydrolase, plc-gamma1
Biological source	Rattus norvegicus (rat)
Cellular location	Cell projection, lamellipodium (By similarity): P10686
Total number of polymer chains	2
Total formula weight	24876.39
Authors	Hajicek, N.,Sondek, J. (deposition date: 2013-04-11, release date: 2013-06-26, Last modification date: 2023-09-20)
Primary citation	Hajicek, N.,Charpentier, T.H.,Rush, J.R.,Harden, T.K.,Sondek, J. Autoinhibition and Phosphorylation-Induced Activation of Phospholipase C-gamma Isozymes. Biochemistry, 52:4810-4819, 2013 Cited by PubMed: 23777354 DOI: 10.1021/bi400433b PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation