4J23
Low resolution crystal structure of the FGFR2D2D3/FGF1/SR128545 complex
Summary for 4J23
Entry DOI | 10.2210/pdb4j23/pdb |
Descriptor | Fibroblast growth factor receptor 2, Fibroblast growth factor 1 (2 entities in total) |
Functional Keywords | protein-protein complex, immunoglobulin c-2 type, receptor domain, fgf binding, transferase, protein binding, membrane protein, signaling protein, signaling protein-transferase complex, signaling protein/transferase |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 40630.00 |
Authors | Kudlinzki, D.,Saxena, K.,Sreeramulu, S.,Schieborr, U.,Dreyer, M.,Schreuder, H.,Schwalbe, H. (deposition date: 2013-02-04, release date: 2014-02-19, Last modification date: 2023-09-20) |
Primary citation | Herbert, C.,Schieborr, U.,Saxena, K.,Juraszek, J.,De Smet, F.,Alcouffe, C.,Bianciotto, M.,Saladino, G.,Sibrac, D.,Kudlinzki, D.,Sreeramulu, S.,Brown, A.,Rigon, P.,Herault, J.P.,Lassalle, G.,Blundell, T.L.,Rousseau, F.,Gils, A.,Schymkowitz, J.,Tompa, P.,Herbert, J.M.,Carmeliet, P.,Gervasio, F.L.,Schwalbe, H.,Bono, F. Molecular mechanism of SSR128129E, an extracellularly acting, small-molecule, allosteric inhibitor of FGF receptor signaling. Cancer Cell, 23:489-501, 2013 Cited by PubMed: 23597563DOI: 10.1016/j.ccr.2013.02.018 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.882 Å) |
Structure validation
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