4IS9

Crystal Structure of the Escherichia coli LpxC/L-161,240 complex

Summary for 4IS9

• Entry DOI: 10.2210/pdb4is9/pdb
• Related: 4ISA
• Descriptor: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ISOPROPYL ALCOHOL, ZINC ION, ... (6 entities in total)
• Functional Keywords: lpxc, deacetylation, antibiotic, acyl udp-glcnac, hydroxamate, l-161, 240, baab sandwich, lipid a biosynthesis, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Escherichia coli
• Total number of polymer chains: 2
• Total formula weight: 67999.36

Authors

Lee, C.-J.,Zhou, P. (deposition date: 2013-01-16, release date: 2013-10-30, Last modification date: 2024-02-28)

• Primary citation: Lee, C.J.,Liang, X.,Gopalaswamy, R.,Najeeb, J.,Ark, E.D.,Toone, E.J.,Zhou, P.; Structural Basis of the Promiscuous Inhibitor Susceptibility of Escherichia coli LpxC.; Acs Chem.Biol., 9:237-246, 2014; PubMed: 24117400; DOI: 10.1021/cb400067g

Experimental method

X-RAY DIFFRACTION (2.13 Å)