4IS9

Crystal Structure of the Escherichia coli LpxC/L-161,240 complex

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0008759	molecular_function	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
A	0009245	biological_process	lipid A biosynthetic process
B	0008759	molecular_function	UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity
B	0009245	biological_process	lipid A biosynthetic process

Functional Information from PDB Data

site_id	AC1
Number of Residues	2
Details	BINDING SITE FOR RESIDUE IPA A 501

Chain	Residue
A	CYS250
A	TYR284

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN A 502

Chain	Residue
A	HIS79
A	HIS238
A	ASP242
A	LTF503

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site_id	AC3
Number of Residues	17
Details	BINDING SITE FOR RESIDUE LTF A 503

Chain	Residue
A	HIS79
A	THR191
A	GLY193
A	ILE198
A	LEU201
A	GLY210
A	SER211
A	ALA215
A	HIS238
A	ASP242
A	HIS265
A	ZN502
A	HOH616
A	HOH721
A	LEU18
A	LEU62
A	GLU78

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site_id	AC4
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ZN B 401

Chain	Residue
B	HIS79
B	HIS238
B	ASP242
B	LTF402

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site_id	AC5
Number of Residues	13
Details	BINDING SITE FOR RESIDUE LTF B 402

Chain	Residue
B	LEU62
B	GLU78
B	HIS79
B	THR191
B	PHE192
B	GLY193
B	ILE198
B	GLY210
B	ALA215
B	HIS238
B	ASP242
B	HIS265
B	ZN401

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site_id	AC6
Number of Residues	1
Details	BINDING SITE FOR RESIDUE NA B 403

Chain	Residue
A	ILE254

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site_id	AC7
Number of Residues	3
Details	BINDING SITE FOR RESIDUE IPA B 404

Chain	Residue
B	TRP144
B	TYR150
B	SER154

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