4ISA
Crystal Structure of the Escherichia coli LpxC/BB-78485 complex
Summary for 4ISA
| Entry DOI | 10.2210/pdb4isa/pdb |
| Related | 4IS9 |
| Descriptor | UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase, ZINC ION, (2R)-N-hydroxy-3-naphthalen-2-yl-2-[(naphthalen-2-ylsulfonyl)amino]propanamide, ... (6 entities in total) |
| Functional Keywords | lipid a synthesis, lpxc, baab sandwich, deacetylation, antibiotic, acyl udp-glcnac, hydroxamate, bb-78485, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Escherichia coli |
| Total number of polymer chains | 1 |
| Total formula weight | 35395.38 |
| Authors | Lee, C.-J.,Zhou, P. (deposition date: 2013-01-16, release date: 2013-10-30, Last modification date: 2024-02-28) |
| Primary citation | Lee, C.J.,Liang, X.,Gopalaswamy, R.,Najeeb, J.,Ark, E.D.,Toone, E.J.,Zhou, P. Structural Basis of the Promiscuous Inhibitor Susceptibility of Escherichia coli LpxC. Acs Chem.Biol., 9:237-246, 2014 Cited by PubMed: 24117400DOI: 10.1021/cb400067g PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.8 Å) |
Structure validation
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