4HFP

Structure of thrombin mutant S195a bound to the active site inhibitor argatroban

Summary for 4HFP

Entry DOI	10.2210/pdb4hfp/pdb
Related	1SHH 4HFY
Related PRD ID	PRD_000889
Descriptor	Prothrombin, SODIUM ION, (2R,4R)-4-methyl-1-(N~2~-{[(3S)-3-methyl-1,2,3,4-tetrahydroquinolin-8-yl]sulfonyl}-L-arginyl)piperidine-2-carboxylic acid, ... (5 entities in total)
Functional Keywords	serine protease, prethrombin-2, autoactivation, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (human) More
Cellular location	Secreted, extracellular space: P00734 P00734
Total number of polymer chains	4
Total formula weight	67885.84
Authors	Pozzi, N.,Chen, Z.,Zapata, F.,Lin, W.,Barranco-Medina, S.,Pelc, L.A.,Di Cera, E. (deposition date: 2012-10-05, release date: 2013-03-13, Last modification date: 2023-09-20)
Primary citation	Pozzi, N.,Chen, Z.,Zapata, F.,Niu, W.,Barranco-Medina, S.,Pelc, L.A.,Di Cera, E. Autoactivation of thrombin precursors. J.Biol.Chem., 288:11601-11610, 2013 Cited by PubMed: 23467412 DOI: 10.1074/jbc.M113.451542 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.4 Å)

Structure validation