4HFP
Structure of thrombin mutant S195a bound to the active site inhibitor argatroban
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Prothrombin | polymer | 31 | 3647.1 | 2 | UniProt (P00734) Pfam (PF09396) | Homo sapiens (human) | Coagulation factor II, Activation peptide fragment 1, Activation peptide fragment 2, Thrombin light chain, Thrombin heavy chain |
| 2 | B, D (B, D) | Prothrombin | polymer | 259 | 29764.2 | 2 | UniProt (P00734) Pfam (PF00089) | Homo sapiens (human) | Coagulation factor II, Activation peptide fragment 1, Activation peptide fragment 2, Thrombin light chain, Thrombin heavy chain |
| 3 | E, G (B, D) | SODIUM ION | non-polymer | 23.0 | 2 | Chemie (NA) | |||
| 4 | F, H (B, D) | (2R,4R)-4-methyl-1-(N~2~-{[(3S)-3-methyl-1,2,3,4-tetrahydroquinolin-8-yl]sulfonyl}-L-arginyl)piperidine-2-carboxylic acid | non-polymer | 508.6 | 2 | BIRD (PRD_000889) Chemie (15U) | |||
| 5 | I, J, K, L (A, B, C, D) | water | water | 18.0 | 66 | Chemie (HOH) |
Sequence modifications
B, D: 16 - 247 (UniProt: P00734)
| PDB | External Database | Details |
|---|---|---|
| Ala 195 | Ser 568 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 66822.6 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 1063.2 | |
| All* | Total formula weight | 67885.8 |
