4GUY
Human MMP12 catalytic domain in complex with*N*-Hydroxy-2-(2-(4-methoxyphenyl)ethylsulfonamido)acetamide
Replaces: 3RTUSummary for 4GUY
| Entry DOI | 10.2210/pdb4guy/pdb |
| Related | 3F15 3F16 3F17 3F1A 3LK8 3NX7 |
| Descriptor | Macrophage metalloelastase, ZINC ION, CALCIUM ION, ... (5 entities in total) |
| Functional Keywords | mmp-12, matrix, metalloproteinase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Homo sapiens (human) |
| Cellular location | Secreted, extracellular space, extracellular matrix : P39900 |
| Total number of polymer chains | 1 |
| Total formula weight | 18023.85 |
| Authors | Calderone, V.,Fragai, M.,Luchinat, C.,Massaro, A.,Mordini, A.,Mori, M. (deposition date: 2012-08-30, release date: 2012-09-19, Last modification date: 2023-11-08) |
| Primary citation | Mori, M.,Massaro, A.,Calderone, V.,Fragai, M.,Luchinat, C.,Mordini, A. Contribution of free energy of solvation to ligand affinity in new potent MMPs inhibitors. To be Published, |
| Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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