4GS7
Structure of the Interleukin-15 quaternary complex
Summary for 4GS7
Entry DOI | 10.2210/pdb4gs7/pdb |
Related | 2b5i 2z3q |
Descriptor | Interleukin-15, Interleukin-2 receptor subunit beta, Cytokine receptor common subunit gamma, ... (9 entities in total) |
Functional Keywords | cytokine, cytokine receptor, immunoregulatory, anti-tumor, anti-viral, reductive methylation, immune system |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 71795.02 |
Authors | Ring, A.M.,Ozkan, E.,Feng, D.,Garcia, K.C. (deposition date: 2012-08-27, release date: 2012-11-07, Last modification date: 2020-07-29) |
Primary citation | Ring, A.M.,Lin, J.X.,Feng, D.,Mitra, S.,Rickert, M.,Bowman, G.R.,Pande, V.S.,Li, P.,Moraga, I.,Spolski, R.,Ozkan, E.,Leonard, W.J.,Garcia, K.C. Mechanistic and structural insight into the functional dichotomy between IL-2 and IL-15. Nat.Immunol., 13:1187-1195, 2012 Cited by PubMed: 23104097DOI: 10.1038/ni.2449 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.35 Å) |
Structure validation
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