4GS7
Structure of the Interleukin-15 quaternary complex
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Interleukin-15 | polymer | 116 | 13080.9 | 1 | UniProt (P40933) Pfam (PF02372) | Homo sapiens (human) | IL-15 |
| 2 | B (B) | Interleukin-2 receptor subunit beta | polymer | 217 | 25152.6 | 1 | UniProt (P14784) Pfam (PF18707) | Homo sapiens (human) | IL-2 receptor subunit beta, IL-2R subunit beta, IL-2RB, High affinity IL-2 receptor subunit beta, p70-75, p75 |
| 3 | C (C) | Cytokine receptor common subunit gamma | polymer | 203 | 24390.3 | 1 | UniProt (P31785) Pfam (PF22012) Pfam (PF21605) | Homo sapiens (human) | Interleukin-2 receptor subunit gamma, IL-2 receptor subunit gamma, IL-2R subunit gamma, IL-2RG, gammaC, p64 |
| 4 | D (D) | Interleukin-15 receptor subunit alpha | polymer | 69 | 7759.0 | 1 | UniProt (Q13261) | Homo sapiens (human) | IL-15 receptor subunit alpha, IL-15R-alpha, IL-15RA, Soluble interleukin-15 receptor subunit alpha, sIL-15 receptor subunit alpha, sIL-15R-alpha, sIL-15RA |
| 5 | E, F (E, F) | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 424.4 | 2 | In PDB GlyTouCan (G42666HT) | |||
| 6 | G (B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 1 | Chemie (EDO) | |||
| 7 | H (C) | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 8 | I, J (C) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 9 | K, L, M, N (A, B, C, D) | water | water | 18.0 | 254 | Chemie (HOH) |
Sequence modifications
A: 1 - 114 (UniProt: P40933)
B: 1 - 214 (UniProt: P14784)
C: 33 - 232 (UniProt: P31785)
D: 0 - 67 (UniProt: Q13261)
| PDB | External Database | Details |
|---|---|---|
| Met -1 | - | expression tag |
| Gly 0 | - | expression tag |
| PDB | External Database | Details |
|---|---|---|
| Ala -2 | - | expression tag |
| Asp -1 | - | expression tag |
| Pro 0 | - | expression tag |
| Gln 3 | Asn 29 | engineered mutation |
| Gln 17 | Asn 43 | engineered mutation |
| Gln 45 | Asn 71 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ala 30 | - | expression tag |
| Asp 31 | - | expression tag |
| Pro 32 | - | expression tag |
| Gln 53 | Asn 75 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Met -1 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 70382.7 | |
| Branched | Number of molecules | 2 |
| Total formula weight | 848.8 | |
| Non-Polymers* | Number of molecules | 4 |
| Total formula weight | 563.5 | |
| All* | Total formula weight | 71795.0 |
