2Z3Q

Crystal structure of the IL-15/IL-15Ra complex

Summary for 2Z3Q

• Entry DOI: 10.2210/pdb2z3q/pdb
• Related: 2Z3R
• Descriptor: Interleukin-15, Interleukin-15 receptor alpha chain (3 entities in total)
• Functional Keywords: protein-protein complex, cytokine-cytokine receptor complex, cytokine/cytokine receptor
• Biological source: Homo sapiens (human); More
• Cellular location: Isoform IL15-S48AA: Secreted. Isoform IL15-S21AA: Cytoplasm: P40933; Membrane; Single-pass type I membrane protein. Isoform 5: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Isoform 6: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Isoform 7: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Isoform 8: Endoplasmic reticulum membrane; Single-pass type I membrane protein. Soluble interleukin-15 receptor subunit alpha: Secreted, extracellular space: Q13261
• Total number of polymer chains: 4
• Total formula weight: 49508.30

Authors

Chirifu, M.,Yamagata, Y.,Davis, S.J.,Ikemizu, S. (deposition date: 2007-06-05, release date: 2007-09-04, Last modification date: 2011-07-13)

• Primary citation: Chirifu, M.,Hayashi, C.,Nakamura, T.,Toma, S.,Shuto, T.,Kai, H.,Yamagata, Y.,Davis, S.J.,Ikemizu, S.; Crystal structure of the IL-15-IL-15Ralpha complex, a cytokine-receptor unit presented in trans; Nat.Immunol., 8:1001-1007, 2007; PubMed: 17643103; DOI: 10.1038/ni1492

Experimental method

X-RAY DIFFRACTION (1.85 Å)