4GRW
Structure of a complex of human IL-23 with 3 Nanobodies (Llama vHHs)
Summary for 4GRW
Entry DOI | 10.2210/pdb4grw/pdb |
Descriptor | Interleukin-23 subunit alpha, Interleukin-12 subunit beta, Nanobody 124C4, ... (7 entities in total) |
Functional Keywords | cytokine, immunoglobulin fold, vhh domain, immune system |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 10 |
Total formula weight | 199002.13 |
Authors | Desmyter, A.,Spinelli, S.,Button, C.,Saunders, M.,de Haard, H.,Rommelaere, H.,Union, A.,Cambillau, C. (deposition date: 2012-08-27, release date: 2014-02-19, Last modification date: 2023-12-27) |
Primary citation | Desmyter, A.,Spinelli, S.,Boutton, C.,Saunders, M.,Blachetot, C.,de Haard, H.,Denecker, G.,Van Roy, M.,Cambillau, C.,Rommelaere, H. Neutralization of Human Interleukin 23 by Multivalent Nanobodies Explained by the Structure of Cytokine-Nanobody Complex. Front Immunol, 8:884-884, 2017 Cited by PubMed: 28871249DOI: 10.3389/fimmu.2017.00884 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.55 Å) |
Structure validation
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