4GAH
Human acyl-CoA thioesterases 4 in complex with undecan-2-one-CoA inhibitor
Summary for 4GAH
Entry DOI | 10.2210/pdb4gah/pdb |
Descriptor | Thioesterase superfamily member 4, [[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(3R)-2,2-dimethyl-3-oxidanyl-4-oxidanylidene-4-[[3-oxidanylidene-3-[2-[(2R)-2-oxidanylundecyl]sulfanylethylamino]propyl]amino]butyl] hydrogen phosphate (3 entities in total) |
Functional Keywords | hotdog fold, acyl coa hydrolase; akt c-terminal modulating protein, acyl-coa, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cell membrane: Q5T1C6 |
Total number of polymer chains | 2 |
Total formula weight | 50738.99 |
Authors | Lim, K.,Pathak, M.C.,Herzberg, O. (deposition date: 2012-07-25, release date: 2012-08-29, Last modification date: 2023-09-13) |
Primary citation | Zhao, H.,Lim, K.,Choudry, A.,Latham, J.A.,Pathak, M.C.,Dominguez, D.,Luo, L.,Herzberg, O.,Dunaway-Mariano, D. Correlation of structure and function in the human hotdog-fold enzyme hTHEM4. Biochemistry, 51:6490-6492, 2012 Cited by PubMed: 22871024DOI: 10.1021/bi300968n PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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