4FLG

HIV-1 protease mutant I47V complexed with reaction intermediate

Summary for 4FLG

• Entry DOI: 10.2210/pdb4flg/pdb
• Related: 3B7V 3B80 4FL8 4FM6
• Descriptor: HIV-1 protease, HIV-1 protease, fragment, GLUTAMIC ACID, ... (10 entities in total)
• Functional Keywords: hydrolase, catalytic mechanism, drug resistance, aspartic protease
• Biological source: Human immunodeficiency virus 1 (HIV-1); More
• Cellular location: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367 P03367 P03367 P03367
• Total number of polymer chains: 5
• Total formula weight: 23314.04

Authors

Yu, X.,Shen, C.H.,Weber, I.T. (deposition date: 2012-06-14, release date: 2012-10-17, Last modification date: 2024-03-13)

• Primary citation: Shen, C.H.,Tie, Y.,Yu, X.,Wang, Y.F.,Kovalevsky, A.Y.,Harrison, R.W.,Weber, I.T.; Capturing the Reaction Pathway in Near-Atomic-Resolution Crystal Structures of HIV-1 Protease.; Biochemistry, 51:7726-7732, 2012; PubMed: 22963370; DOI: 10.1021/bi3008092

Experimental method

X-RAY DIFFRACTION (1.31 Å)