4FLG
HIV-1 protease mutant I47V complexed with reaction intermediate
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | B, A | HIV-1 protease | polymer | 99 | 10726.6 | 2 | UniProt (P03367) Pfam (PF00077) In PDB | Human immunodeficiency virus 1 (HIV-1) | PR, Retropepsin |
| 2 | C | HIV-1 protease, fragment | polymer | 4 | 487.5 | 1 | UniProt (P03367) In PDB | Human immunodeficiency virus 1 (HIV-1) | |
| 3 | E | HIV-1 protease, fragment | polymer | 3 | 372.5 | 1 | UniProt (P03367) In PDB | Human immunodeficiency virus 1 (HIV-1) | |
| 4 | F | HIV-1 protease, fragment | polymer | 3 | 373.4 | 1 | UniProt (P03367) In PDB | Human immunodeficiency virus 1 (HIV-1) | |
| 5 | B | GLUTAMIC ACID | non-polymer | 147.1 | 1 | Chemie (GLU) | |||
| 6 | B | ISOLEUCINE | non-polymer | 131.2 | 1 | Chemie (ILE) | |||
| 7 | B | SODIUM ION | non-polymer | 23.0 | 1 | Chemie (NA) | |||
| 8 | B, A | CHLORIDE ION | non-polymer | 35.5 | 4 | Chemie (CL) | |||
| 9 | A | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 10 | water | water | 18.0 | 184 | Chemie (HOH) |
Sequence modifications
B, A: 1 - 99 (UniProt: P03367)
| PDB | External Database | Details |
|---|---|---|
| Lys 7 | Gln 507 | engineered mutation |
| Ile 33 | Leu 533 | engineered mutation |
| Val 47 | Ile 547 | engineered mutation |
| Ile 63 | Leu 563 | engineered mutation |
| Ala 67 | Cys 567 | engineered mutation |
| Ala 95 | Cys 595 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 22686.7 | |
| Non-Polymers* | Number of molecules | 9 |
| Total formula weight | 627.3 | |
| All* | Total formula weight | 23314.0 |
