4FM6

HIV-1 protease mutant V32I complexed with reaction intermediate

Summary for 4FM6

Entry DOI	10.2210/pdb4fm6/pdb
Related	3B7V 3B80 4FL8 4FLG
Descriptor	HIV-1 protease, hexapeptide, SODIUM ION, ... (6 entities in total)
Functional Keywords	hydrolase, catalytic mechanism, drug resistance, aspartic protease
Biological source	Human immunodeficiency virus 1 (HIV-1) More
Cellular location	Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P03367
Total number of polymer chains	3
Total formula weight	22601.09
Authors	Shen, C.H.,Weber, I.T. (deposition date: 2012-06-15, release date: 2012-10-17, Last modification date: 2023-09-13)
Primary citation	Shen, C.H.,Tie, Y.,Yu, X.,Wang, Y.F.,Kovalevsky, A.Y.,Harrison, R.W.,Weber, I.T. Capturing the Reaction Pathway in Near-Atomic-Resolution Crystal Structures of HIV-1 Protease. Biochemistry, 51:7726-7732, 2012 Cited by PubMed: 22963370 DOI: 10.1021/bi3008092 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.4 Å)

Structure validation